The purpose of this investigation was to evaluate the healing process of toothash-plaster mixture combined with lyophilized dura mater membrane at the bony defects.
Full-thickness bony defects were made on the three sites of dog calvaria. Group 1 was filled with the blood clots, group 2 : toothash-plaster mixture, Group 3 : toothash-plaster mixture covered with lyophilized dura mater. Radiographic,
macroscopic
and
microscopic examinations were taken after 2, 4, 8, 12 and 24 weeks after operation.
Radiographically, the early new bone formation was appeared from the host bone at group 3. Macros copically, the defect of group 1 was collapsed and filled with connective tissue throughout the experimental period. But the defect of group 2 and 3
was
tightly united with the host bone and showed the hard consistency on palpation. Lyodura was partially resorbed and still remained at the original site Microscopically, the inflammatory and foreign body reaction were disappeared as time is over.
There
were much connective tissue at the central part of group 1. But the defects of group 2 and 3 were filled with the mature bony trabeculae. The implanted particles were resorbed gradually and replaced with the newly formed bone.
This results suggest that a lyophilized dura mater can effectively be used as a barrier membrane for guided bony regeneration and toothash-plaster mixture combined with GBR may be a useful adjunct in cases requiring the reconstruction of bony
defects.
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